Unscheduled DNA synthesis: Some statistical thoughts |
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| Authors: | Ajit K. Thakur |
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| Affiliation: | (1) Biostatistics Department, Hazleton Laboratories America, Inc., Vienna, Virginia;(2) Hazleton Laboratories America, Inc., Biostatistics Department, 9200 Leesburg Turnpike, 22180 Vienna, VA |
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| Abstract: | Statistical interpretation of results of experiments involving unscheduled DNA synthesis is examined from a design standpoint. Most appropriate methods currently in use are evaluated and some modifications and extensions are suggested. Concerns about replication and/or interaction errors are evaluated and methods for their appropriate handling are discussed. It is suggested that methods incorporating both dose-response and heterogeneity statistics should be considered in treating results from unscheduled DNA synthesis experiments. Proper designs for such experiments are emphasized.Abbreviations ANOVA analysis of variance - MSE mean square error - UDS unscheduled DNA synthesis |
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| Keywords: | design dose-response heterogeneity power sample size UDS |
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