Embryonic chick intestine in organ culture: stimulation of calcium transport by exogenous vitamin D-induced calcium-binding protein. |
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| Authors: | R A Corradino C S Fullmer R H Wasserman |
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| Affiliation: | Department of Physical Biology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 U.S.A. |
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| Abstract: | Vitamin D3 or a potent metabolite, 1,25-dihydroxycholecalciferol, induces calcium-binding protein (CaBP) synthesis and stimulates transmucosal calcium transport in embryonic chick duodena maintained in novel organ culture apparatus. When added to the sterol-free culture medium, highly purified chick intestinal CaBP, similarly and specifically, stimulates calcium transport in the cultured duodena. These results clearly demonstrate the involvement of CaBP in intestinal calcium transport. |
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