Anxiety and behavior in WAG/Rij strain rats with genetically induced absence attacks |
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Authors: | Kliueva Iu A Chepurnova N E Berdiev R K Mart'ianov A A Mogimi A Chepurnov S A |
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Institution: | Lomonosov State University, Moscow. |
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Abstract: | Behavior of nonlinear rats and animals from Wistar and WAG/Rij (with inborn generalized absence epilepsy) strains was examined in the elevated plus-maze and the hole board. WAG/Rij rats demonstrated low exploratory behavior in both tests. In the elevated plus-maze, WAG/Rij rats were more balanced and more anxious than Wistar and nonlinear rats. Administration of ethosuximide completely eliminated spike-wave discharges but did not change behavioral interstrain differences. Since the spike-wave patterns develop in WAG/Rij at the age of 3 months, the behavior of young (2-moth-old) pups from different strains was compared and significant differences were revealed. Correlation between the genetically defined features (spike-wave discharges) and behavioral peculiarities in WAG/Rij rats is supposed. |
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