Hypothesis dual hormonal regulation of sodium balance

The concept that prostaglandins may antagonize the renin-angiotensin system and increase sodium excretion must now be modified. New information that prostaglandin A₁ stimulates aldosterone in man, and that sodium restriction increases both prostaglandin A and aldosterone levels, suggests the possibility that prostaglandins, as well as angiotensin II, may stimulate aldosterone secretion. This dual system could result in additive or synergistic effects on aldosterone secretion. In addition, there is the possibility that angiotensin-induced vasoconstriction might be counteracted by prostaglandin-induced vasodilation.