Compensatory increase in adrenomedullary angiotensin-converting enzyme activity (kininase II) after unilateral adrenalectomy |
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| Authors: | A Israel Y Barbella J M Saavedra |
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| Affiliation: | 1. Faculty of Pharmacy, Central University of Venezuela, Caracas, Venezuela;2. Unit of Preclinical Neuropharmacology, Section of Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Health, Bethesda, MD 20892, U.S.A.;1. School of Biomedical Engineering, Shenzhen University, Shenzhen, Guangdong, 518060, China;2. Shenzhen Refresh Intelligent Technology Co., Ltd., Shenzhen, Guangdong, 518060, China;1. Diabetes Research Institute, Mills-Peninsula Health Services, San Mateo, CA, USA;2. University of California, Los Angeles, Los Angeles, CA, USA;3. University of Nebraska Medical Center, Omaha, NE, USA;1. Department of Endocrinology, University Hospitals Leuven–KU Leuven, Leuven, Belgium;2. Interuniversity Institute for Biostatistics and Statistical Bioinformatics, KU Leuven and University of Hasselt, Leuven, Belgium;3. Department of Endocrinology-Diabetology-Metabolism, University Hospital Antwerp, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;4. Academic Hospital and Diabetes Research Centre, Vrije Universiteit Brussel, Brussels, Belgium;5. Department of Endocrinology, OLV Hospital Aalst, Aalst, Belgium;6. Department of Endocrinology, Imeldaziekenhuis Bonheiden, Bonheiden, Belgium;7. Department of Endocrinology, AZ Groeninge, Kortrijk, Belgium;1. Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 69 Jesse Hill Jr. Dr., Glenn Building, Suite 202, Atlanta, GA, 30303, USA;2. Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Ave, Suite 530, Chicago, IL 60611, USA;1. Kings College Hospital NHS Foundation Trust, London, UK;2. Leicester Diabetes Centre, University of Leicester, Leicester, UK;3. Diabetologische Schwerpunktpraxis, Bergheim, Germany;4. Schwerpunktpraxis für Diabetes und Ernährungsmedizin, Münster, Germany;5. Zentrum für Diabetologie Bergedorf, Hamburg, Germany;6. Hospices Civils de Lyon (DIAB-e CARE), Lyon, France;7. Wellcome Trust-MRC Institute of Metabolic Science and Department of Medicine, University of Cambridge, Cambridge, UK;8. Medtronic International Trading Sàrl, Tolochenaz, Switzerland;9. Medtronic, Northridge, California, USA;10. Medtronic Bakken Research Center, Maastricht, Netherlands |
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| Abstract: | Angiotensin-converting enzyme (ACE, kininase II, dipeptidyl carboxypeptidase, EC 3.4.15.1) was characterized in the adrenal medulla of male Sprague-Dawley rats. Rat adrenal medulla and lung ACE were similar in their susceptibility to Cl- activation and to the inhibition by EDTA, captopril, bacitracin and thiorphan, suggesting that rat adrenal medulla and lung ACE have similar properties. Changes in right adrenal weight and in adrenomedullary ACE activity 5 and 12 days following left unilateral adrenalectomy (UADX) were examined. Compensatory adrenocortical hypertrophy 12 days following UADX was associated with a significant increase in adrenal medullary ACE activity. This change was due not to a modified affinity of ACE for the substrate but to an alteration in ACE maximal velocity or number of available molecules. UADX had no effect on adrenocortical ACE activity. When UADX was combined with right splanchnic denervation, the increase in adrenomedullary ACE activity was blocked. The results support the existence of a functional ACE in adrenal medulla that is under neuronal control. |
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