Quantitative measurement of indomethacin crystallinity in indomethacin-silica gel binary system using differential scanning calorimetry and X-ray powder diffractometry |
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| Authors: | Xiaohong Pan Thomas Julian Larry Augsburger |
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| Affiliation: | (1) School of Pharmacy, University of Maryland, 20 North Pine Street, 21201 Baltimore, MD;(2) Wyeth, 401 North Middletown Road, Building 230/1073, 10965 Pearl River, NY;(3) Genta, 2 Connell Drive, 07922 Berkeley Heights, NJ |
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| Abstract: | Differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD) methods were developed for the quantitative analysis of the crystallinity of indomethacin (IMC) in IMC and silica gel (SG) binary system. The DSC calibration curve exhibited better linearity than that of XRPD. No phase transformation occurred in the IMC-SG mixtures during DSC measurement. The major sources of error in DSC measurements were inhomogeneous mixing and sampling. Analyzing the amount of IMC in the mixtures using high-performance liquid chromatography (HPLC) could reduce the sampling error. DSC demonstrated greater sensitivity and had less variation in measurement than XRPD in quantifying crystalline IMC in the IMC-SG binary system. Published: February, 10, 2006 |
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| Keywords: | Differential scanning calorimetry X-ray powder diffractometry crystallinity quantitative analysis indomethacin silica gel amorphization |
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