修正非齐次马尔可夫模型应用的研究

修正非齐次模型是在齐次模型和非齐次模型基础上提出的适用于蛋白质编码区的马尔可夫模型。此模型可以用来分析生物物种进化和基因突变,模型中的马尔可夫度与序列进化水平相关联,转移矩阵与基因突变相关联。本文通过比较7类不同物种-1度马尔可夫链的含量,验证了生物物种进化反映在密码子使用上的特征;通过密码子位点间转移矩阵的计算,分析了基因突变在密码子不同位点上发生的可能性。

Research on the application of the modified non-homogeneous markov model

Based on homogeneous model and non - homogeneous model, the modified non - homogeneous Markov model deals with codon preference and primary sequence structure in protein - coding regions, reflects more accurately the key biological features:amino acid usage and codon preference bias.The modified model studies the relation of molecule evolution with Markov chain of order k,and the relation of gene mutation with transition matrix,It is demonstrated,via an example, the numeber of Markov chain of older- 1 in one biological species reflects the level of the species in the biological evolution system. At the same time, the model studies the probability of gene mutation at each codon position baaed on transition matrix.