Design,synthesis, molecular docking and anti-hepatocellular carcinoma evaluation of novel acyclic pyridine thioglycosides |
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| Authors: | Galal H. Elgemeie Nahed M. Fathy Ayman B. Farag Sheikha A. Alkhursani |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo, Egypt;2. Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt;3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt;4. Chemistry Department, Girls College of Science, Dammam, Kingdom of Saudi Arabia |
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| Abstract: | A novel series of acyclic pyridine thioglycosides has been synthesized. Evaluation of the anti proliferative activity of these compounds against HEPG-2 cell lines (liver carcinoma cell lines) shows that most of the compounds have high anti-tumor activities especially 6b, 6c, 7b and 7c. Furthermore, in the modeling study, these compounds showed that they have high binding affinity with thymidylate synthase dihydrofolate reductase (TS-DHFR). |
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| Keywords: | Acyclic pyridine thioglycosides thioglycosides cytotoxic activity thymidylate synthase dihydrofolate reductase (TS-DHFR) anti-tumor activity docking studies |
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