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Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients |
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| Authors: | Frahm Silke Kurtz Andreas Kluwe Lan Farassati Faris Friedrich Reinhard E Mautner Victor F |
| Affiliation: | (1) Laboratory of Brain Tumor Biology, Department of Neurosurgery, University Hospital Eppendorf, Hamburg, Germany;(2) Department of Neurosurgery, Massachussetts General Hospital, Charlestown, MA, USA;(3) Department of Maxillofacial Surgery, University Hospital Eppendorf, Hamburg, Germany |
| Abstract: | BackgroundMalignant peripheral nerve sheath tumors (MPNSTs) are neoplasms leading to death in most cases. Patients with Neurofibromatosis type 1 have an increased risk of developing this malignancy. The metabolites of the inactive prodrug Sulindac, Sulindac Sulfide and Sulindac Sulfone (Exisulind) are new chemopreventive agents that show promising results in the treatment of different cancer types. In this study we examined the antineoplastic effect of these compounds on primary cells derived from two MPNSTs of Neurofibromatosis type 1 patients. |
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