A fusion protein containing a lepidopteran-specific toxin from the South Indian red scorpion (Mesobuthus tamulus) and snowdrop lectin shows oral toxicity to target insects |
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| Authors: | Nghia Pham Trung Elaine Fitches John A Gatehouse |
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| Institution: | (1) School of Biological and Biomedical Sciences, University of Durham, Science Laboratories, South Road, Durham, DH1 3LE, UK;(2) Central Science Laboratory, Department for Environment, Food and Rural Affairs, Sand Hutton, York, YO41 1LZ, UK;(3) Department of Biotechnology, Cuu Long Delta Rice Research Institute, O Mon, Can Tho, Viet Nam |
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| Abstract: | Background Despite evidence suggesting a role in plant defence, the use of plant lectins in crop protection has been hindered by their
low and species-specific insecticidal activity. Snowdrop lectin (Galanthus nivalis agglutinin; GNA) is transported to the haemolymph of insects after oral ingestion, and can be used as a basis for novel insecticides.
Recombinant proteins containing GNA expressed as a fusion with a peptide or protein, normally only toxic when injected into
the insect haemolymph, have the potential to show oral toxicity as a result of GNA-mediated uptake. |
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