Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions |
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Authors: | Judit Balogh Dorottya Kiss Judit Dredán István Puskás Ferenc Csempesz Romána Zelkó |
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Institution: | (1) Harvard Medical School, Boston, Massachusetts, USA;(2) Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC), Boston, USA |
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Abstract: | The physical stability of 2 types of total nutrient admixtures was studied as a function of storage time and temperature.
One of them contained only structured triglycerides and the other exclusively long-chain triglycerides as lipid components.
To evaluate the possible changes in the kinetic stability of the emulsions and in the surface characteristics of the droplets
during storage, particle size analysis, zeta potential, and dynamic surface tension measurements were performed. To follow
any chemical decomposition processes that occurred during storage, the pH of the emulsions was also monitored. The mean droplet
size of emulsions prepared with lipids containing exclusively long-chain triglycerides showed a remarkable increase after
4 days of storage, in contrast with that of the mixtures containing structured lipids. A combination of size distribution,
zeta potential, and dynamic surface tension measurements proved to be useful for an adequate tracking of the kinetic stability
of total nutrient admixtures. Structured triglycerides not only provide advantageous metabolic effects but improve the physical
stability of total parenteral nutrition admixtures. |
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Keywords: | Nutrient admixtures structured triglycerides long-chain triglycerides kinetic stability zeta potential dynamic surface tension |
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