The role of leptin in innate and adaptive immune responses |
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| Authors: | Eiva Bernotiene Gaby Palmer Cem Gabay |
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| Institution: | (1) Department of Experimental Research, Institute of Experimental and Clinical Medicine, Vilnius University, Vilnius, Lithuania;(2) Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland;(3) Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland; |
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| Abstract: | Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results
in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays
an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and
during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a
proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results,
suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans. |
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