Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties |
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| Authors: | Maria Vega Flores |
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| Affiliation: | Department of Molecular Medicine & Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand |
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| Abstract: | Reactive oxygen species (ROS) function in a range of physiological processes such as growth, metabolism and signaling, and also have a pathological role. Recent research highlighted the requirement for ROS generated by dual oxidase (DUOX) in host-defence responses in innate immunity and inflammatory disorders such as inflammatory bowel disease (IBD), but in vivo evidence to support this has, to date, been lacking. In order to investigate the involvement of Duox in gut immunity, we characterized the zebrafish ortholog of the human DUOX genes. Zebrafish duox is highly expressed in intestinal epithelial cells. Knockdown of Duox impaired larval capacity to control enteric Salmonella infection. |
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| Keywords: | ROS, reactive oxygen species Duox, dual oxidase IBD, inflammatory bowel disease IECs, intestinal epithelial cells TLRs, Toll-like receptors NOD, nucleotide oligomerization domain hpf, hours post-fertilization dpf, days post-fertilization hpi, hours post-infection |
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