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In silico experimentation with a model of hepatic mitochondrial folate metabolism |
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| Authors: | H Frederik Nijhout Michael C Reed Shi-Ling Lam Barry Shane Jesse F Gregory III Cornelia M Ulrich |
| Affiliation: | (1) Department of Biology, Duke University, 27708 Durham, NC, USA;(2) Department of Mathematics, Duke University, 27708 Durham, NC, USA;(3) Department of Nutrition Sciences and Toxicology, University of California, 94720-3104 Berkeley, CA, USA;(4) Department of Food Science and Human Nutrition, University of Florida, 32611-0370, USA;(5) Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 98109-1024 Seattle, WA, USA |
| Abstract: | BackgroundIn eukaryotes, folate metabolism is compartmentalized and occurs in both the cytosol and the mitochondria. The function of this compartmentalization and the great changes that occur in the mitochondrial compartment during embryonic development and in rapidly growing cancer cells are gradually becoming understood, though many aspects remain puzzling and controversial. |
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