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Proteome-level display by 2-dimensional chromatography of extracellular matrix-dependent modulation of the phenotype of bladder cancer cells |
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| Authors: | Robert E Hurst Kimberly D Kyker Mikhail G Dozmorov Nobuaki Takemori Anil Singh Hiroyuki Matsumoto Ricardo Saban Edna Betgovargez Michael H Simonian |
| Institution: | (1) Department of Urology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA;(2) Department of Biochemistry and Molecular Biology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA;(3) Department of Occupational and Environmental Health, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA;(4) Department of Physiology, Oklahoma University Health Sciences Centre, Oklahoma City, OK 73104, USA;(5) Biomedical Research Division, Beckman Coulter Inc., 4300 N. Harbor Blvd., Fullerton, CA 92834, USA |
| Abstract: | BackgroundThe extracellular matrix can have a profound effect upon the phenotype of cancer cells. Previous work has shown that growth of bladder cancer cells on a matrix derived from normal basement membrane suppresses many malignant features that are displayed when the cells are grown on a matrix that has been modified by malignant tumors. This work was undertaken to investigate proteome-level changes as determined by a new commercially available proteome display involving 2-dimensional chromatography for bladder cancer cells grown on different extracellular matrix preparations that modulate the expression of the malignant phenotype. |
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