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A New Estimation Method for Noncompartmental Pharmacokinetic Analysis |
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| Authors: | H Knolle |
| Abstract: | The mathematical tools of Hilbert space theory and Gauß quadrature are used to derive a new method of curve fitting and calculation of statistical moments of the concentration-time curve. |
| Keywords: | Pharmacokinetics Area under the curve Mean residence time Parameter estimation (curve fitting) Orthogonal polynomials |