High-level acetaldehyde production in Lactococcus lactis by metabolic engineering |
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| Authors: | Bongers Roger S Hoefnagel Marcel H N Kleerebezem Michiel |
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| Institution: | NIZO food research, Department of Flavour and Natural Ingredients, P.O. Box 20, 6710 BA Ede, The Netherlands. Roger.Bongers@nizo.nl |
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| Abstract: | Efficient conversion of glucose to acetaldehyde is achieved by nisin-controlled overexpression of Zymomonas mobilis pyruvate decarboxylase (pdc) and Lactococcus lactis NADH oxidase (nox) in L. lactis. In resting cells, almost 50% of the glucose consumed could be redirected towards acetaldehyde by combined overexpression of pdc and nox under anaerobic conditions. |
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