Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents |
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| Authors: | Donkor Isaac O Jones Susan K Tidwell Richard R |
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| Affiliation: | College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125. |
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| Abstract: | Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease. |
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