Neonatal hypoxia-ischemia induces sex-related changes in rat brain mitochondria |
| |
| Authors: | Weis Simone N Pettenuzzo Leticia F Krolow Rachel Valentim Lauren M Mota Carina S Dalmaz Carla Wyse Angela T S Netto Carlos Alexandre |
| |
| Affiliation: | 1. Laboratorio de Virología: agentes antivirales y citoprotectores, Departamento de Química Biológica — IQUIBICEN, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina;2. IBYME (CONICET) and Departamento de Química Biológica — IQUIBICEN, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina;3. Departamento de Química Orgánica and UMYMFOR (CONICET — Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428EGA, Argentina;3. Gene Therapy Center, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil;4. Surgery Unit, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil;5. Gastroenterology Unit, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil;2. Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil |
| |
| Abstract: | The effects of neonatal hypoxia-ischemia (HI) on energy metabolism in male and female rats were investigated, testing the hypothesis that HI-induced brain mitochondrial dysfunction could present in a dimorphic pattern. Impairment in electron transport chain complex activities at 2 and 18 h after HI was observed in cortex and hippocampus in rats of both sexes, with females presenting an overall activity higher than that of males. Females also showed loss of mitochondrial mass and membrane potential 18 h after HI, while males were only slightly affected. These findings suggest a dimorphism in mitochondrial dysfunction and provide information that may lead to new neuroprotection strategies. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
