Comparison of Japanese isolates of Coxiella burnetii by PCR-RFLP and sequence analysis |
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| Authors: | Andoh Masako Nagaoka Hiromi Yamaguchi Tsuyoshi Fukushi Hideto Hirai Katsuya |
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| Institution: | Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, Gifu, Gifu 501-1193, Japan. |
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| Abstract: | The genetic variation of Japanese isolates of Coxiella burnetii, the agent of Q fever, was found for the first time. Forty-nine out of 72 isolates had the chronic pattern of the isocitrate hydrogenase gene. Sequence analysis revealed that the isolates have a specific nucleotide sequence. The putative amino acid sequence was the same as that of chronic reference strains. These results suggest the variation of C. burnetii isolates in Japan. |
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| Keywords: | com1 gene coxiella burnetii icd gene PCR‐RFLP |
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