Increased cyclic GMP in the end-plate region of denervated frog muscle

Denervated frog sartorius muscles showed an approximately 2–3 fold increase of cyclic GMP in their end-plate rich regions which did not appear up to 5 weeks after denervation in the normally end-plate-free pelvic region. No increase in cyclic AMP was seen in these preparations. The results suggest that the increase of cyclic GMP is related to processes specific to the region in which end plates are normally present.