| 免疫细胞衰老表现及免疫功能变化的研究进展 |
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| 引用本文： | 黄丽映,刘韬.免疫细胞衰老表现及免疫功能变化的研究进展[J].中华细胞与干细胞杂志(电子版),2020,10(2):119-124. |
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| 作者姓名： | 黄丽映 刘韬 |
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| 作者单位： | 1. 515041 汕头，广东省汕头大学医学院；518001 深圳大学第三附属医院 （深圳市罗湖区人民医院）肿瘤康复科 |
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| 基金项目： | 深圳市科技计划项目(JCYJ20170412155231633，JCYJ201 70307171034705) |
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| 摘 要： | 机体衰老的本质是细胞衰老不断累积的过程。免疫系统的衰老既是机体衰老的必然结果,也是导致机体衰老的重要原因。免疫系统作为衰老变化的主要系统之一受到越来越多的学者重视。本文将从适应性免疫系统的T、B细胞及固有免疫系统的自然杀伤(NK)细胞、巨噬细胞、中性粒细胞、树突状细胞(DC)和骨髓源性抑制细胞等免疫细胞的亚群、衰老指标和功能等方面在衰老过程中的改变进行总结,进一步明确免疫系统衰老在机体衰老过程中扮演的重要角色。
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| 关 键 词： | 免疫衰老 T细胞 NK细胞 炎症 |
| 收稿时间： | 2019-09-03 |
Advances in senescence phenotypes of immune cells and immune function |
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| Authors: | Liying Huang Tao Liu |
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| Institution: | 1. Shantou University Medical College, Shantou 515041, China; Department of Oncology and Rehabilitation, Shenzhen Luohu People's Hospital, the 3rd Affiliated Hospital of Shenzhen University, Shenzhen 518001, China |
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| Abstract: | The essence of the body's aging was the process of accumulating cell senescence.The senescence of the immune system was not only the inevitable result of the body's aging,but also an important cause of the body's aging.The immune system,as one of the main systems of aging changes,had attracted scholars'attention.This review systematically summarized the changes from the adaptive immune system T,B cells and innate immune system natural killer(NK)cells,macrophages,neutrophils,dendritic cells,bone marrow-derived cells and other immune cells groups.And also,we tried to state aging indicators,functions and other aspects of the changes in the aging process.All together,we further clarified the important role of immune system senescence in the body aging process. |
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| Keywords: | Immunosenescence T cells NK cells Inflammation |
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