Metabolite concentrations in the liver of the adult and developing guinea pig and the control of glycolysis in vivo. |
| |
Authors: | A Faulkner C T Jones |
| |
Institution: | Nuffield Institute for Medical Research, University of Oxford, Headley Way, Headington, Oxford OX3 9DS, England |
| |
Abstract: | A range of metabolite concentrations have been determined in the liver of the adult and fetal guinea pig during the latter half of gestation. Adenine nucleotides showed little change during development of the fetal liver and the only major difference from the adult was a low ADP concentration. The hexose phosphates, particularly fructose 1,6-diphosphate, were higher and the triose phosphates in the glycolytic pathway after glyceraldehyde 3-phosphate were lower in the fetal liver. Cytosolic ratios were comparable in both adult and fetal livers as were cytosolic ratios for the last 15–20 days of gestation. The metabolite concentrations have been used to indicate that glycolysis in the fetal guinea pig liver is controlled largely by hexokinase, glyceraldehyde 3-phosphate dehydrogenase, and pyruvate kinase. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|