Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model |
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Authors: | Alvin S. Stern Randolph V. Lewis Sadao Kimura Jean Rossier Stanley Stein Sidney Udenfriend |
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Affiliation: | Roche Institute of Molecular Biology, Department of Physiological Chemistry and Pharmacology, Nutley, New Jersey 07110 U.S.A. |
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Abstract: | Bovine adrenal chromaffin granules have been shown to contain [Met]enkephalin and [Leu]enkephalin and at least seven other small peptides that exhibit specific binding to opiate receptors. Six of these peptides have been characterized and their structures established as (O)-[Met]enkephalin, [Met]enkephalin-Arg6-Arg7, [Met]enkephalin-Lys6, [Met]enkephalin-Arg6, [Leu]enkephalin-Arg6, and [Met]enkephalin-Arg6-Phe7. Many of these hexa- and heptapeptides are also present in bovine and human brain. It is suggested that the presence of these peptides in a tissue is evidence of a common biosynthetic pathway of the enkephalins from a large precursor protein. |
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