Multi-level reproducibility of signature hubs in human interactome for breast cancer metastasis |
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| Authors: | Chen Yao Hongdong Li Chenggui Zhou Lin Zhang Jinfeng Zou Zheng Guo |
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| Institution: | 1.Bioinformatics Centre and Key Laboratory for NeuroInfomation of the Education Ministry of China, School of Life Science, University of Electronic Science and Technology of China,Chengdu,China;2.Colleges of Bioinformatics Science and Technology, Harbin Medical University,Harbin,China |
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| Abstract: | Background It has been suggested that, in the human protein-protein interaction network, changes of co-expression between highly connected
proteins ("hub") and their interaction neighbours might have important roles in cancer metastasis and be predictive disease
signatures for patient outcome. However, for a cancer, such disease signatures identified from different studies have little
overlap. |
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