Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases |
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| Authors: | Yuko Takahashi Shiori Haga Yukihito Ishizaka Akio Mimori |
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| Institution: | (1) Division of Rheumatic Diseases, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan;(2) Department of Intractable Diseases, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan |
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| Abstract: | Introduction Angiotensin-converting enzyme (ACE) 2, a homolog of ACE, converts angiotensin (Ang) II into Ang(1-7), and the vasoprotective
effects of Ang(1-7) have been documented. We explored the hypothesis that serum autoantibodies to ACE2 predispose patients
with connective tissue diseases to constrictive vasculopathy, pulmonary arterial hypertension (PAH), or persistent digital
ischemia. |
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