Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis |
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Authors: | Zhao Zhenjiang Xu Yufang Qian Zhigang Tian Wenhong Qian Xuhong Zhong Jian-Jiang |
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Affiliation: | Shanghai Key Lab. of Chemical Biology, Institute of Pesticides and Pharmaceuticals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. |
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Abstract: | To develop more effective abiotic elicitors for cell suspension cultures of T. chinensis to meet the needs for paclitaxel as anti-tumor drug, some fluoro- or hydroxyl-containing groups are introduced to the ester moiety of jasmonic acid by the esterification or acylation with bis(trichloromethyl) carbonate and corresponding alcohol. Some of them are found to be novel and effective elicitors, which can enhance the production of taxuyunnanine C (Tc) up to 60% more than that by methyl jasmonate (MJA) in T. chinensis cell cultures. |
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