The heat shock proteins: Their roles as multi-component machines for protein folding |
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Authors: | Barry Panaretou Chao Zhai |
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Affiliation: | aPharmaceutical Science Division, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom |
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Abstract: | The roles played by heat shock proteins in fungi have been subjected to intense scrutiny. Presuming they only played roles in tolerance to stress gave way to the realization that many of them were essential for maintenance of cell physiology under all conditions. Recent progress has revealed their action as multi-component machines, playing roles in signalling and expansion of phenotypic plasticity, as well as their well-established function as molecular chaperones. |
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Keywords: | Chaperones Heat shock proteins |
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