Antiviral activity of phorbol myristate acetate and possible relationships with interferon action |
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Authors: | Gyrgy Premecz Andrea Markovits Istvn Fldes |
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Institution: | György Premecz, Andrea Markovits,István Földes |
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Abstract: | Signal-induced turnover of membrane phospholipids represents a fundamental transducing mechanism that induces a signal cascade resulting in mobilization of calcium, activation of protein kinase C by diacylglycerol, release of arachidonic acid and stimulation of cyclic GMP production. In this pathway tumor-promoting phorbol esters such as phorbol myristate acetate (PMA) may substitute for diacylglycerol. The interferonlike antiviral effect of PMA described here suggests that the inositol phospholipid-diacylglycerol-protein kinase C signal-transducing mechanism may be involved in interferon action. |
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Keywords: | Antiviral activity Phorbol ester Second messenger Interferon action Phosphatidylinositol turnover |
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