Cadherin-7 function in zebrafish development |
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Authors: | Liu Qin Marrs James A Londraville Richard L Wilson Amy L |
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Affiliation: | Department of Biology, University of Akron, Akron, OH 44325, USA, qliu@uakron.edu. |
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Abstract: | Cadherin cell adhesion molecules play crucial roles in vertebrate development. Most studies have focused on examining the functions of classical type I cadherins (e.g., cadherin-2) in the development of vertebrates. Little information is available concerning the function of classical type II cadherins (e.g., cadherin-7) in vertebrate development. We have previously shown that cadherin-7 mRNA exhibits a dynamic expression pattern in the central nervous system and notochord in embryonic zebrafish. To gain insight into the role of cadherin-7 in the formation of these structures, we analyzed their formation in zebrafish embryos injected with cadherin-7-specific antisense morpholino oligonucleotides (MO). Notochord development was severely disrupted in MO-injected embryos, whereas gross defects in the development of the central nervous system were not detected in MO-injected embryos. Our results thus demonstrate that cadherin-7 plays an important role in the normal development of the zebrafish notochord. |
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Keywords: | Cell adhesion molecules Notochord Central nervous system Antisense morpholino oligonucleotides Zebrafish, Danio rerio (Teleostei) |
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