13C-Leucine-tracer-technique for in-vivo measurement of amino acids' metabolism by human colon carcinomas期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

13C-Leucine-tracer-technique for in-vivo measurement of amino acids' metabolism by human colon carcinomas

Authors:	E Hagmüller H -J Günther H D Saeger H Kolmar J -P Striebel Y Ghoos

Institution:	(1) Surgical Clinic, University Heidelberg, Mannheim, Federal Republic of Germany;(2) Department of Anaesthesia, University Clinic, Mannheim, Federal Republic of Germany;(3) Universitaire Ziekenhuizen, Leuven, Belgium;(4) Chirurgische Klinik, Klinikum Mannheim der Universität Heidelberg, D-W-6800 Mannheim, Bundesrepublik Deutschland

Abstract:	Summary Own investigations on in-vivo tumor metabolism of the malignant human colon tumor showed a significant uptake of branched chain amino acids by the tumor itself. To study the quantitative tumor protein metabolism (compartment tumor) the¹³C-leucine-tracer-technique was modified.Beside the common¹³C-leucine-breath-test we measured also the AV-differences of¹³C-leucine,¹³C-ketoisocaproate and¹³CO₂. The Tumorblood flow was measured by venous-outflow-technique as well as the tumor mass.In this way it is possible to get quantitative results in substrate exchange of branched chain amino acids in malignant human colon tumors.

Keywords:	Amino acids Stable isotopes ¹³C-Leucine Tumor metabolism Malignant colon tumor
本文献已被 SpringerLink 等数据库收录！