Solution structure of the DNA complex with a quinacrine-netropsin hybrid molecule by NMR spectroscopy. |
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| Authors: | Y Kubota S Tani R Uchida |
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| Institution: | Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi 753-8512, Japan. |
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| Abstract: | The solution structures of 1:1 complexes of a quinacrine-netropsin hybrid molecule with the self-complementary DNA duplexes, d(CGCGAATTCGCG)2 and d(CGAATTCG)2, have been studied by one- and two-dimensional 1H NMR spectroscopy. The NOE data indicate that the acridine ring of the hybrid intercalates into the 5'-GpA step and its netropsin moiety spans the minor groove of the central AATT region. |
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