A transferable plasmid associated with AS-48 production in Enterococcus faecalis. |
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| Authors: | M Martínez-Bueno A Glvez E Valdivia and M Maqueda |
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| Institution: | M Martínez-Bueno, A Gálvez, E Valdivia, and M Maqueda |
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| Abstract: | Enterococcus faecalis S-48 produces a peptide antibiotic, AS-48, and a bacteriocin, Bc-48. We have isolated mutants that lack these inhibitory characteristics. Further analysis of the mutants indicates that a plasmid of 56 kilobases (pMB2) may harbor the genes for AS-48. In conjugation experiments, pMB2 has been transferred into a plasmid-free OG1X strain of E. faecalis. The OG1X(pMB2) transconjugant produces the antibiotic AS-48 in solid medium, and the MIC of AS-48 for this strain is the same as that of the donor strain. |
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