Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats |
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| Authors: | Chengwen Chen Qianbo Chen Yanfei Mao Shengming Xu Chunyan Xia Xueyin Shi John H Zhang Hongbin Yuan Xuejun Sun |
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| Institution: | (1) Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 200003 Shanghai, People’s Republic of China;(2) Department of SICU, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China;(3) Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China;(4) Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China;(5) Department of Neurosurgery, Loma Linda University, Loma Linda, CA, USA;(6) Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, 200433 Shanghai, People’s Republic of China; |
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| Abstract: | In the present study, we examined the mechanisms of hydrogen-rich saline, a reported therapeutic antioxidant, in the treatment
of acute spinal cord contusion injury. Male Sprague-Dawley rats were used to produce a standardized model of contuses spinal
cord injury (125 kdyn force). Hydrogen-rich saline was injected intraperitoneally (5 ml/kg) immediately, and at 24 and 48 h
after injury. All rats were sacrificed at 72 h after spinal cord injury (SCI). Apoptotic cell death, oxidative stress, inflammation,
level of Brain derived neurotrophic factor (BDNF) were evaluated. In addition, locomotor behavior was assessed using the Basso,
Beattice and Bresnahan (BBB) scale. We observed that administration of hydrogen-rich saline decreased the number of apoptotic
cells, suppressed oxidative stress, and improved locomotor functions. Hydrogen-rich saline increased the release of BDNF.
In conclusion, hydrogen-rich saline reduced acute spinal cord contusion injury, possibly by reduction of oxidative stress
and elevation of BDNF. |
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