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Withaferin A sensitizes TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of death receptor 5 and down-regulation of c-FLIP
Authors:Tae-Jin Lee  Hee Jung Um  Do Sik Min  Jong-Wook Park  Kyeong Sook Choi  Taeg Kyu Kwon  
Institution:1. Department of Immunology, School of Medicine, Keimyung University, 194 Dong San-Dong Jung-Gu, Taegu 700-712, South Korea;2. Department of Anatomy, College of Medicine, Yeungnam University, 317-1 Daemyoung-Dong Nam-Gu, Taegu 705-717, Korea;3. Department of Molecular Biology, College of Natural Science, Pusan National University, Pusan, Korea;4. Department of Molecular Science and Technology, Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea;1. Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea;2. Department of Physiology and Biomedical Sciences, Seoul National University, Seoul, Republic of Korea;3. National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;1. Universidad de Granada, Facultad de Ciencias. Departamento de Análisis Matemático, 18071 Granada, Spain;2. Department of Mathematics, POSTECH, Pohang (790-784), Republic of Korea;3. Poznań University of Technology, Piotrowo 3A, 60-965 Poznań, Poland;4. School of Mathematics, Korea Institute for Advanced Study (KIAS), 85 Hoegiro, Dongdaemun-gu, Seoul 130-722, Republic of Korea;5. Department of Mathematics Education, Dongguk University - Seoul, 100-715 Seoul, Republic of Korea;6. Universidade de Sao Paulo, Instituto de Matemática e Estatística, CP 66281 CEP:05311-970 São Paulo, Brazil;1. Department of Mathematics Education, Korea University, Seoul 136-701, Republic of Korea;2. Department of Mathematics, Seoul National University, Seoul 151-747, Republic of Korea;3. School of Mathematics, Korea Institute for Advanced Study, Seoul 130-722, Republic of Korea;1. Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-4838, Tehran, Iran;2. School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea
Abstract:
Keywords:Withaferin A  ROS  TRAIL  DR5  c-FLIP  CHOP  NF-κ  B  Free radicals
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