Exploring the role of insect host factors in the dynamics of Trypanosoma cruzi-Rhodnius prolixus interactions |
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Authors: | Garcia Eloi S Ratcliffe Norman A Whitten Miranda M Gonzalez Marcelo S Azambuja Patricia |
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Institution: | a Department of Biochemistry and Molecular Biology, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro 21045-900, RJ, Brazil b Department of Biological Sciences, University of Wales, Swansea, Singleton Park, Swansea SA2 8PP, Wales, UK c Institut de Biologie Moleculaire et Cellulaire, CNRS, 15 Rue Rene Descartes, 67084 Strasbourg, France d Department of General Biology, Universidade Federal Fluminense s/n Niterói, RJ, Brazil |
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Abstract: | Members of the subfamily Triatominae, family Reduviidae, comprise a large number of insect species of which some are vectors of Trypanosoma cruzi, the causative agent of Chagas' disease. This article outlines research on the process of transformation and the dynamics of developmental stages of Trypanosoma cruzi in the triatomine insect hosts. Special attention is given to the interactions of parasites with gut molecules, and the gut environment, and with host developmental physiology and intestinal organization. The vector insect's permissiveness to Trypanosoma cruzi, which develops in the vector gut, largely depends on the host nutritional state, the parasite strain, trypanolytic compounds, digestive enzymes, lectins, resident bacteria in the gut and the endocrine system of the insect vector. Finally, the mechanisms of these interactions and their significance for Trypanosoma cruzi transmission are discussed. |
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Keywords: | Trypanosoma cruzi Triatomines Vector Parasites |
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