| Characterisation and molecular typing of Burkholderia pseudomallei: Are disease presentations of melioidosis clonally related? |
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| 收稿时间： | 1997-09-10 |
Characterisation and molecular typing of Burkholderia pseudomallei: Are disease presentations of melioidosis clonally related? |
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| R Norton ,B Roberts,M Freeman,M Wilson,C Ashhurst-Smith,W Lock,D Brookes,J La,Brooy. Characterisation and molecular typing of Burkholderia pseudomallei: Are disease presentations of melioidosis clonally related?[J]. FEMS immunology and medical microbiology, 1998, 20(1): 37-44. DOI: 10.1016/S0928-8244(97)00104-1 |
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| Authors: | R Norton B Roberts M Freeman M Wilson C Ashhurst-Smith W Lock D Brookes J La Brooy |
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| Affiliation: | Townsville General Hospital, Townsville, Queensland 4810, Australia;Department of Biomedical and Tropical Veterinary Science, James Cook University, Townsville, Queensland, Australia;Department of Clinical Microbiology, Townsville General Hospital, Townsville, Queensland, Australia;Mornington Island Hospital, Mornington Island, Queensland, Australia;Tropical Public Health Unit, Cairns, Queensland, Australia |
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| Abstract: | Eighteen cases of culture positive melioidosis caused by Burkholderia pseudomallei, were seen in four geographically separate communities in North Queensland, Australia. The genetic inter-relatedness of the clinical isolates were compared utilising random amplification of polymorphic DNA (RAPD) and multilocus enzyme electrophoresis (MEE). The isolates segregated into two groups that correlated with clinical presentation rather than geographical location. This is the first described association between the varied clinical presentations of this condition and specific molecular type. If proven on larger studies, this may further our understanding of the pathogenesis of this important condition. |
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| Keywords: | Melioidosis Burkholderia pseudomallei Molecular typing |
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