Lymphocyte and neutrophil dysfunction associated with hepatitis B virus and hepatitis non-A, non-B virus infection in the chimpanzee. |
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Authors: | L J Lafrado M A Javadian J M Marr K A Wright J C Kelliher C S Dezzutti L Cummins R G Olsen |
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Institution: | Ohio State University, Center for Retrovirus Research, Columbus. |
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Abstract: | Chimpanzees were examined for the effect of viral hepatitis infections on specific and nonspecific immune response mechanisms. The data suggest that infection with either hepatitis B virus or hepatitis non-A, non-B virus may result in suppression of cellular immune response components. Mitogen-induced lymphocyte proliferation was lower in virus-infected chimpanzees than in naive animals. Neutrophils from virus infected animals exhibited decreased or altered chemiluminescence kinetics. |
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Keywords: | chimpanzee viral hepatitis immunosuppression |
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