| 氟哌啶醇和（R—）—NPA抑制C6神经胶质瘤细胞的钾电流 |
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| 引用本文： | 谢重 何淑舫. 氟哌啶醇和（R—）—NPA抑制C6神经胶质瘤细胞的钾电流[J]. 生理学报, 1997, 49(1): 45-53 |
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| 作者姓名： | 谢重 何淑舫 |
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| 作者单位： | 中国科学院上海脑研究所!上海，200031，中国科学院上海脑研究所!上海，200031 |
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| 基金项目： | 上海生命科学联合开放研究实验室资助!932105 |
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| 摘 要： | 本工作用全细胞膜片箝方法，观察了氟啶醇（ｈａｌｏｐｅｒｉｄｏｌ以下简称ＨＡＬＯ）和Ｒ（－）－Ｐｒｏｐｙｌｎｏｒａｐｏｍｏｒｐｈｉｎｅ（以下简称ＮＰＡ）对Ｃ６神经胶质瘤细胞（Ｃ６ｇｌｉｏｍａｃｅｌｌｓ）的电压依赖性钾电流的作用，并初步分析了它们的作用机制。结果表明，ＨＡＬＯ和ＮＰＡ都能抑制Ｃ６细胞的Ｋ＾＋Ｊ电流中的慢成分，而对快成分的作用有所不同。它们的抑制作用不是由多巴胺Ｄ２受体介导的，也不是通过
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| 关 键 词： | 神经胶质瘤 癌细胞 氟哌啶醇 多巴胺受体 钾电流 |
INHIBITION OF VOLTAGE-DEPENDENT K~ CURRENTS IN RAT C_6 GLIOMA CELLS BY HALOPERIDOL AND R(-)-NPA |
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| XIE ZHONG, HE SHU-FANG. INHIBITION OF VOLTAGE-DEPENDENT K~ CURRENTS IN RAT C_6 GLIOMA CELLS BY HALOPERIDOL AND R(-)-NPA[J]. Acta Physiologica Sinica, 1997, 49(1): 45-53 |
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| Authors: | XIE ZHONG HE SHU-FANG |
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| Abstract: | In this study, the inhibitory effects of R (-) - NPA (R (-) - Propylnorapomorphine) and haloperidol on voltage-dependent K currents in rat C6 glioma cells (C6 eells) were observed by means of the whole-cell patch-clamp recording technique.The mechanisms of the effects were aiso analyzed. The main results were as follows:(1) Both R (-) -NPA and haloperidol could inhibit K currents dose-dependently andreversibly in C6 cells. (2) R (-) -NPA and haloperidol inhibited mainly the slow component of the K currents. (3) These inhibitory respollas were not mediated bydopamine receptors or dependent on G-proteins and intracellular calcium. It was suggested they refer to some direct action on K channels. |
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| Keywords: | haloperidol R (-) - Propylnorapomorphine C_6 glioma celis K~ currents whole-cell patch-clamp recording |
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