Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs |
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| Authors: | Makarov Vadim A Riabova Olga B Granik Vladimir G Dahse Hans-Martin Stelzner Axel Wutzler Peter Schmidtke Michaela |
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| Institution: | Department of Medicinal Chemistry, Research Center for Antibiotics, 3a Nagatinskaya str., Moscow 117105, Russia. |
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| Abstract: | A novel class of 2-amino-4-nitropyrazolo1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo1,5-a]pyrimidines as key steps. |
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