Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion |
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Authors: | Ferrer-Sueta Gerardo Vitturi Dario Batinic-Haberle Ines Fridovich Irwin Goldstein Sara Czapski Gidon Radi Rafael |
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Institution: | Laboratorio de Fisicoquímica Biológica, Facultad de Ciencias, Universidad de la República, Montevideo 11400, Uruguay. |
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Abstract: | We have studied the reaction kinetics of ten manganese porphyrins, differing in their meso substituents, with peroxynitrite (ONOO-) and carbonate radical anion (CO3.) using stopped-flow and pulse radiolysis, respectively. Rate constants for the reactions of Mn(III) porphyrins with ONOO- ranged from 1 x 10(5) to 3.4 x 10(7) m(-1) s(-1) and correlated well with previously reported kinetic and thermodynamic data that reflect the resonance and inductive effects of the substituents on the porphyrin ring. Rate constants for the reactions of Mn(III) porphyrins with CO3. ranged from 2 x 10(8) to 1.2 x 10(9) m(-1)s(-1) at pH
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