Biotechnological production of enantiopure epoxides by enzymatic kinetic resolution |
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Authors: | Won Jae Choi |
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Institution: | (1) Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore |
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Abstract: | Enantiopure epoxides are high value-added synthons for the production of pharmaceuticals, agrochemicals, as well as versatile
fine chemicals and have broad scope of market demand for their applications. A major challenge in conventional organic synthesis
is to generate such compounds in high enantiopurity with reasonable yield. Among possible chemical and biological technologies
for enantiopure epoxide preparation, enzymatic kinetic resolution has been paid much attention with respect to its high enantioselectivity.
Epoxide hydrolase (EH) has shown promising characteristics for the preparation of enantiopure epoxides and vicinal diols during
enantioselective hydrolysis of racemic epoxides. EH is readily available from microbial resources thus it is being employed
for biohydrolysis of a variety of epoxides. Recent technical progress in EH-catalyzed enantioselective hydrolysis is summarized
in terms of exploration of novel EH, its functional improvement, high throughput assay, and preparative scale resolution process. |
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Keywords: | Enantiopure epoxides Kinetic resolution Epoxide hydrolase Enantioselective hydrolysis |
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