Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring |
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Authors: | Tanitame Akihiko Oyamada Yoshihiro Ofuji Keiko Fujimoto Mika Suzuki Kenji Ueda Tomohiko Terauchi Hideo Kawasaki Motoji Nagai Kazuo Wachi Masaaki Yamagishi Jun-ichi |
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Affiliation: | Chemistry Research Laboratories, Dainippon Pharmaceutical Co. Ltd, 33-94 Enoki, Suita, Osaka 564-0053, Japan. akihiko-tanitame@dainippon-pharm.co.jp |
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Abstract: | The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-piperidyl)pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and topoisomerase IV with similar IC(50) values (IC(50)=9.4-25 microg/mL). In addition, many of the pyrazole, oxazole and imidazole derivatives synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates and coumarin-resistant laboratory isolates of Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains. |
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