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1H, 13C,and 15N NMR assignments of a Drosophila Hedgehog autoprocessing domain |
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| Authors: | Jian Xie Zhenming Du Brian Callahan Marlene Belfort Chunyu Wang |
| Affiliation: | 1. Biochemistry and Biophysics Graduate Program, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA 2. Department of Chemistry, State University of New York at Binghamton, Binghamton, NY, 13902, USA 3. Department of Biological Sciences, University at Albany, Albany, NY, 12222, USA |
| Abstract: | The Hedgehog (Hh) signaling pathway plays important roles in embryonic growth and patterning in different organisms. Abnormal activity of the Hh signaling pathway has been associated to cancers, holoprosencephaly and autism spectrum disorders. The backbone and side chain resonance assignments of a Drosophila Hh autoprocessing domain have been determined based on triple-resonance experiments with the [13C, 15N]-labeled and [2H, 13C, 15N])-labeled proteins. |
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