Cellular differentiation and antibody localization during the primary immune response in peroxidase stimulated lymph nodes of rat |
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| Authors: | W D Kuhlmann S Avrameas |
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| Affiliation: | 1. College of Food Science and Technology, Henan University of Technology, Zhengzhou, Henan 450001, PR China;2. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China;1. Chinese Research Academy of Environmental Sciences, Beijing 100012, China;2. State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;1. Electronics Integration Laboratory, University of Applied Science Kempten, Germany;2. Vaas Leiterplattentechnik GmbH, Schwäbisch-Gmünd, Germany |
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| Abstract: | The development of antihorseradish peroxidase-producing cells was studied by electron microscopic immunocytochemistry in rat popliteal lymph node after a single immunization of antigen with complete Freund's adjuvant. Specific antibody synthesis could be observed during the maturation stages of two morphologically distinct cell types from the blast cell to the ergastoplasm-rich cell stage of either lymphocyte-like or reticulum-like cells. The first antihorseradish peroxidase antibodies were localized on Day 5 after immunization in some ergastoplasmic cisternae of mature plasma cells but not in blast cells. Specific antibody could be localized in typical blast cells from Day 6. In earlier days of the immune response blast cells occurred in increased numbers; however, antihorseradish peroxidase antibodies could not be localized with the methods employed. |
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