Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development |
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Authors: | Benninger Yves Thurnherr Tina Pereira Jorge A Krause Sven Wu Xunwei Chrostek-Grashoff Anna Herzog Dominik Nave Klaus-Armin Franklin Robin J M Meijer Dies Brakebusch Cord Suter Ueli Relvas João B |
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Affiliation: | Institute of Cell Biology, Department of Biology, Eidgen?ssische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland. |
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Abstract: | During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles. |
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