| TNF受体家族介导的细胞凋亡信号转导 |
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| 引用本文： | 萨其拉,刘孟珉,贺福初. TNF受体家族介导的细胞凋亡信号转导[J]. 生物化学与生物物理进展, 1999, 26(4): 327-330 |
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| 作者姓名： | 萨其拉 刘孟珉 贺福初 |
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| 作者单位： | 军事医学科学院放射医学研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金重点项目(39730270)和国家自然科学基金面上项目(39800026)资助. |
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| 摘 要： | 肿瘤坏死因子（TNF）家族是一类多功能的细胞因子，具有诱导细胞凋亡、抗病毒、免疫调节等多种生物学活性.其中一些成员可以通过和细胞膜上相应受体（即TNF受体家族成员）结合，启动细胞内的凋亡机制，而诱导细胞凋亡.一些蛋白质（如TRADD、FADD、RIP、RAIDD等）参与这些信号传递过程.越来越多的TNF家族成员、TNF受体以及与细胞凋亡相关的Caspase蛋白酶家族成员被人们发现.
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| 关 键 词： | TNF 细胞凋亡，信号转导 |
| 收稿时间： | 1998-05-18 |
| 修稿时间： | 1998-08-03 |
The Signal Transduction of TNF Receptor Family Induced Apoptosis |
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| Satschr,LIU Meng-Min and HE Fu-Chu. The Signal Transduction of TNF Receptor Family Induced Apoptosis[J]. Progress In Biochemistry and Biophysics, 1999, 26(4): 327-330 |
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| Authors: | Satschr LIU Meng-Min HE Fu-Chu |
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| Affiliation: | Beijing Institute of Radiation Medicine, Beijing 100850, China;Beijing Institute of Radiation Medicine, Beijing 100850, China;Beijing Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract: | The tumor necrosis factor ( TNF ) family is a group of cytokines with multiple biological activities, including cytotoxity, anti-viral activity, immunoregulatory activities and so on. The members of the TNF family induce apoptosis by binding to their specific receptors on target cells and initiate mechanism of apoptosis in the cells. Some proteins like TRADD, FADD, RIP, TAIDD are found to participate in these signal transduction pathways. More and more novel TNF ligands, TNF receptors and caspase family members have been found. |
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| Keywords: | TNF receptor apoptosis signal transduction |
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