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The effect of coagulation factors polymorphisms on abortion
Authors:Narjes Feizollahi  Zeinab Deris Zayeri  Najme Moradi  Mahvash Zargar  Hadi Rezaeeyan
Institution:1.Shahid Beheshti University of Medical Sciences and Health Services,Tehran,Iran;2.Golestan Hospital Clinical Research Development Unit,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran;3.Thalassemia & Hemoglobinopathy Research Center, Research Institute of Health,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran;4.Obstetrics & Gynaecology Department,Ahvaz Jundishapur University of Medical Sciences,Ahvaz,Iran
Abstract:

Objective

Recent studies showed coagulation factors play important role in controlling pregnancy duration in addition to controlling homeostasis. Recent studies showed several polymorphisms of coagulation factors genes increase the clot formation and lead to abortion. In this study, we evaluated the polymorphisms of coagulation factors and their effects on the development of the fetus.

Material and Methods

Relevant literature was identified by a PubMed search (1988-2017) of English language papers using the terms Abortion, pregnancy woman, coagulation factor and polymorphism.

Result

Several polymorphisms of coagulation factors disturb the exchange of food and other materials between the fetus and the mother, and impairs the formation of the placenta during embryonic stages.

Discussion

Evaluation of functional polymorphisms in coagulation factors gene during fetal development can be used as a prognostic factor in the prevention of the abortion.
Keywords:
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