Regulatory T cell: a protection for tumour cells |
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Authors: | Wang Yi Ma Yushui Fang Ying Wu Shengdi Liu Lili Fu Da Shen Xizhong |
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Affiliation: | The Department of Gastroenterology of Zhongshan Hospital, Fudan University, Shanghai, China. |
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Abstract: | Characterized by immunosuppression regulatory T cells (Tregs) play a key role in maintaining immune tolerance. A growing number of tumours have been found with Tregs accumulating in microenvironment and patients with high density of Tregs in tumour stroma get a worse prognosis, which suggests that Tregs may inhibit anti-tumour immunity in stroma, resulting in a poor prognosis. In this paper, we demonstrate the accumulation of Tregs in tumour stroma and the possible suppressive mechanisms. We also state the immunotherapy that has being used in animal and clinical trials. |
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Keywords: | Tregs TGF‐β IL‐10 Foxp3 |
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