Endothelial nitric oxide synthase: a determinant of TNFalpha production by human monocytes/macrophages |
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| Authors: | Mühl Heiko Pfeilschifter Josef |
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| Institution: | Pharmazentrum frankfurt, Klinikum der Johann Wolfgang Goethe-Universit?t Frankfurt am Main, Frankfurt am Main, Germany. H.Muehl@em.uni-frankfurt.de |
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| Abstract: | Until recently endothelial nitric oxide synthase (eNOS) has been associated exclusively with physiological functions, particularly in the cardiovascular system. However, increasing evidence has been accumulated that supports the concept for a role of eNOS in pathophysiology. In particular, detection of eNOS protein and activity in human monocytes/macrophages suggest an immunomodulatory role of this enzyme. Here, we review data that promote the hypothesis that by enhancing TNFalpha production, eNOS activity should be regarded as a novel pro-inflammatory parameter in human monocytes/macrophages. |
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| Keywords: | Endothelial nitric oxide synthase Inducible nitric oxide synthase Inflammation Monocytes Macrophages Tumor necrosis factor-α l-arginine" target="_blank">NG-monomethyl-l-arginine |
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